Jul 1, 2016 | Newsletters
Metabolic labels offer straightforward approaches to directly address the three central pathways of molecular biology, namely replication, transcription and translation in life cells. Acting as analogues of natural biomonomers, metabolic labels are applied to their cellular target by simple feeding, being incorporated into the corresponding biopolymers by the usual enzymatic machinery. Combined with modern CLICK Chemistry, structural alterations induced by the label can be minimized, thereby permitting excellent enzymatic acceptance and mutually orthogonal labeling.