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The “6th base” in DNA

5-Hydroxymethylcytosine (5-hmC) research tools
The so-called “6th base” 5-hydroxymethylcytosine (5-hmC) is a DNA modification that is an important epigenetic marker associated with e.g. stem cell differentiation and brain development.

5-hydroxymethylated DNA fragments can be used as sequencing control[5-9] or for pull-down of 5-hmC-binding proteins from cellular lysate[10]. They are typically generated by enzymatic incorporation of 5-hmdCTP.



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