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INCOGNITO™ RNA synthesis

You can now make disguised RNA by in vitro synthesis which escapes the innate immunity of cells to get translated at much higher levels than the regular RNA. Biotech Desk brings to you the INCOGNITO™ RNA Transcription Kits from Cellscript, USA. These kits contain modified nucleosides, such as pseudouridine (Ψ) and/or 5-methylcytidine (m5C) in place of the corresponding U or C canonical nucleosides.

INCOGNITO RNA for various genes such as KLF4, LIN28, cMYC, SOX2 have been transfected into fibroblasts and keratinocytes and resulted in highly efficient generation of induced pluripotent stem cells. This has possible applications in regenerative medicine and immunotherapies.

Cellscript also sells products for general in vitro transcription, 5′ RNA capping, 3’RNA polyadenylation for making translation ready mRNA.



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